Facile Synthesis, and Antimicrobial activity of Imidazole derivatives by Zirconia NPs catalyst

Abstract

            Imidazole derivatives are considered potential chemical compounds that could be therapeutically effective against several harmful pathogenic microbes. In the present study  substituted imidazoles via nano zirconia catalyzed multicomponent reaction of isatin derivatives with ammonium acetate and substituted indole-3- aldehydes has been developed. The synthesized imidazole derivatives were characterised using spectral and analytical data viz; nuclear magnetic resonance (NMR) , IR  and ¹³ CNMR. The results of antibacterial and antifungal and antioxidant activities showed that some of the synthesized compounds exhibited promising activities.