Noval Schiff base, 4-(2-Chloro-5-nitrobenzylideneamino)-5-mercapto-3-methyl-1,2,4-triazole and its metal complexes: spectroscopic, electron spin resonance, fluorescence and antimicrobial studies

Abstract

The Schiff base, 4-(2-Chloro-5-nitrobenzylideneamino)-5-mercapto-1,2,4-triazole (HL) derived from 4-Amino-5-mercapto-3-methyl-1,2,4-triazoles with 2-Chloro-5-nitrobenzaldehyde has been synthesized by reflux. Co(II) and Ni(II) complexes of the Schiff base were prepared and characterized by spectral studies (UV-vis, IR, Fluorescence), elemental analysis, thermal and magnetic moment measurements. An octahedral geometry for Co(II) and Ni(II) has been proposed on the basis of spectral and thermal techniques. The presence of coordinated water in the 1:1 metal complexes was confirmed by Infra Red and Thermogravimetric method. The metal complexes were screened against gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and yeast (Candida albicans and Saccharomyces cerevisiae) to evaluate their antimicrobial activity.