Phytochemical analysis, anticancer and antioxidant studies of TRIVENI plants: In-vitro studies

Abstract

The TRIVENI include Azadirachta indica (neem), Ficus religiosa (peepal), and Ficus benghalensis (bohar) are recognized for their rich cultural significance and therapeutic benefits in traditional Indian medicine. In the present study, the extracts from the TRIVENI plants were prepared for phytochemical, cytotoxic effects (MIAPACA pancreatic cancer cell line and Fr2 breast epithelial cell line) and antioxidant potential (DPPH) studies. The results from the present study suggested that the TRIVENI plants possess phenols and flavonoids contents. The TRIVENI extracts showed anticancer potential against MIAPACA pancreatic cancer cell line and safe on Fr2 breast epithelial cell line. The free radical induced oxidative stress can cause gene mutations to increase transcription factors for cancer so antioxidants can be effective to reduce cancer progress. Interestingly, in the present study, extracts also showed antioxidant properties by sequencing free radicals, which indicates its potential against cancer. Therefore, further in-vivo studies on antioxidant and anticancer potential of TRIVENI plant would be beneficial to explore the mechanism of action.