IN-VIVOTOXICITYSTUDYANDSCREENINGOFIMMUNOMODULATORY ACTIVITY

Abstract

SURESH CHANDRA¹, DR. SHOAEB MOHAMMAD SYED²

Traditional medicine makes extensive use of Curcuma species (family: Zingiberaceae) to address a variety of immune-related conditions. Their ethnopharmacological usage have been backed by numerous scientific investigations into their immunomodulatory effects. The article provided a critical analysis of the immunomodulatory properties of Curcuma plant different species, examined potential avenues for further study, and provided pertinent perspectives on the facilities as a potential source of novel immunomodulators to regulate. In vivo trials using the plants' crude extracts were the main focus of pharmacological investigations into their immunomodulatory effects. There was a dearth of mechanistic research into the underlying mechanisms, and most of the bioactive metabolites with immunomodulatory properties had already been identified. By the end of the 14-day study, haematological parameters had been examined. Clinical trials for the development of immunomodulatory drugs cannot be pursued without further comprehensive toxicity investigations and investigation into exploring the fundamental processes of immune-related disorders using in vivo laboratory model animals.