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“SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME ARYLIDENENALONONITRILES AND ARYLIDENENITRILE ESTERS AS CYTOTOXIC AGENT”

ABDULRASHID UMAR* , KALID. A. ALAMRY AND HASSAN M. FAIDALLAH Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203 Jeddah 21589, Saudi Arabia

Abstract:-

A series of arylidenenalononitriles1a-g and arylidenenitrile esters 2a-gsupported with some functionalities reported to contribute to significant chemotherapeutic potential were synthesized and evaluated for their cytotoxic activity. Six compounds exhibited cytotoxic potential against a panel of three human tumor cell lines. Compounds 1b, 1dand1gproved to be the most active agents with a broad spectrum of cytotoxic activity. Analogs1b and 1gwere considered as the most active cytotoxic agent, being about two times more active than doxorubicin against the colon HT29 carcinoma cell line.

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