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Synthesis and Biological Evaluation of some New 4,4'-(1,4-Phenylene)bis(6-substituted-2-oxo-1,2-dihydropyridine-3-carbonitrile)derivatives as Anticancer and antiviral Agents.

Hassan M Faidallah* & Nawal M. S. Al.Kabkabi Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203 Jeddah 21589, Saudi Arabia


A series of 4,4'-(1,4-phenylene)bis(6-substituted-2-oxo-1,2-dihydropyridine-3-carbonitrile) and other heterocyclic systems have been synthesized via two synthetic strategies. The structures of the newly synthesized compounds were substantiated by diverse spectroscopic and analytical data. The cytotoxic and antiviral activities of some of the prepared compounds were examined. The results reveled that some compounds have significant cytotoxic activity, while only four derivatives were able to inhibit the hepatitis-C virus RNA (+) and (–) strands at 10-100 μg/mL concentration range.

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