Herbal medicines play an important role in primary health care which ensures safety, efficacy and cost effective. The current study is to evaluate anti-arthritic activity of leaf extract of Myxopyrum smilacifolium Blume. The plant leaves were collected, dried and extracted by using the solvent ethanol. Further the extract was subjected for anti-arthritic activity by Complete Freund’s Adjuvant Induced Arthritis (CFA) model using Wistar albino rats weighing about 150-200g of either sex. The rats were divided into five groups containing six rats each. Primly CFA was injected for induction of arthritis followed by the treatment with 200mg/kg and 400mg/kg of ethanolic extract of Myxopyrum smilacifolium Blume where Diclofenac sodium 10mg/kg was taken as standard. The animals were examined for inflammatory, haematological parameters and the joints were radiographically analysed. Further the ethanolic extract was subjected for phytochemical investigations by Infra red (IR), Nuclear Magnetic Resonance (NMR) and Mass spectroscopy.
Cyclocondensation of chalcones 1a-f with the appropriate hydrazine afforded the corresponding 1,4- Bis(1,3-disubstituted-4,5-dihydro-1H-pyrazol-5-yl)benzene. Mild oxidation of these pyrazolines with bromine water yielded the corresponding pyrazoles derivatives. Biological screening of the prepared compounds revealed weak anticancer activity of these derivatives.